Polycomb group protein-mediated repression of transcription
The polycomb group (PcG) proteins are essential for the normal development of multicellular
organisms. They form multi-protein complexes that work as transcriptional repressors of
several thousand genes controlling differentiation pathways during development. How the
PcG proteins work as transcriptional repressors is incompletely understood, but involves
post-translational modifications of histones by two major PcG protein complexes: polycomb
repressive complex 1 and polycomb repressive complex 2.
organisms. They form multi-protein complexes that work as transcriptional repressors of
several thousand genes controlling differentiation pathways during development. How the
PcG proteins work as transcriptional repressors is incompletely understood, but involves
post-translational modifications of histones by two major PcG protein complexes: polycomb
repressive complex 1 and polycomb repressive complex 2.
The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.
cell.com