[HTML][HTML] Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease
SM de la Monte, T Luong, TR Neely, D Robinson… - Laboratory …, 2000 - Elsevier
Aging is associated with impaired mitochondrial function caused by accumulation of oxygen
free radical-induced mitochondrial (Mt) DNA mutations. One prevailing theory is that age-
associated diseases, including Alzheimer's disease (AD), may be precipitated, propagated,
or caused by impaired mitochondrial function. To investigate the role of MtDNA relative to
genomic (Gn) DNA damage in AD, temporal lobe samples from postmortem AD (n= 37) and
control (n= 25) brains were analyzed for MtDNA and GnDNA fragmentation, mitochondrial …
free radical-induced mitochondrial (Mt) DNA mutations. One prevailing theory is that age-
associated diseases, including Alzheimer's disease (AD), may be precipitated, propagated,
or caused by impaired mitochondrial function. To investigate the role of MtDNA relative to
genomic (Gn) DNA damage in AD, temporal lobe samples from postmortem AD (n= 37) and
control (n= 25) brains were analyzed for MtDNA and GnDNA fragmentation, mitochondrial …
