C-reactive protein as a predictor of mild cognitive impairment conversion into Alzheimer's disease dementia

A Fernandes, M Tábuas-Pereira, D Duro, M Lima… - Experimental …, 2020 - Elsevier
Background and aims Increasing evidence suggests that inflammation plays an important
role in brain aging and neurodegeneration. Pathological studies demonstrate the presence
of C-reactive protein (CRP) in the senile plaques and neurofibrillary tangles in Alzheimer's
disease (AD) brain tissue suggesting that CRP may play a role in its neuropathological
processes. Some findings suggest that midlife elevations of serum CRP are a risk factor for
AD. However, others found lower CRP levels in mild or moderate AD than in controls …