Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease

R Lardenoije, DLA van den Hove, M Havermans… - Molecular and Cellular …, 2018 - Elsevier
Both aging and Alzheimer's disease (AD) are associated with widespread epigenetic
changes, with most evidence suggesting global hypomethylation in AD. It is, however,
unclear how these age-related epigenetic changes are linked to molecular aberrations as
expressed in animal models of AD. Here, we investigated age-related changes of epigenetic
markers of DNA methylation and hydroxymethylation in a range of animal models of AD, and
their correlations with amyloid plaque load. Three transgenic mouse models, including the …