mTOR as a central hub of nutrient signalling and cell growth
J Kim, KL Guan - Nature cell biology, 2019 - nature.com
J Kim, KL Guan
Nature cell biology, 2019•nature.comThe highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally
known as mammalian target of rapamycin) is a central cell growth regulator connecting
cellular metabolism and growth with a wide range of environmental inputs as part of mTOR
complex 1 (mTORC1) and mTORC2. In this Review, we introduce the landmark discoveries
in the mTOR field, starting from the isolation of rapamycin to the molecular characterizations
of key components of the mTORC signalling network with an emphasis on amino acid …
known as mammalian target of rapamycin) is a central cell growth regulator connecting
cellular metabolism and growth with a wide range of environmental inputs as part of mTOR
complex 1 (mTORC1) and mTORC2. In this Review, we introduce the landmark discoveries
in the mTOR field, starting from the isolation of rapamycin to the molecular characterizations
of key components of the mTORC signalling network with an emphasis on amino acid …
Abstract
The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally known as mammalian target of rapamycin) is a central cell growth regulator connecting cellular metabolism and growth with a wide range of environmental inputs as part of mTOR complex 1 (mTORC1) and mTORC2. In this Review, we introduce the landmark discoveries in the mTOR field, starting from the isolation of rapamycin to the molecular characterizations of key components of the mTORC signalling network with an emphasis on amino acid sensing, and discuss the perspectives of mTORC inhibitors in therapeutic applications.
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