mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function
Genetic-and diet-induced obesity and insulin resistance are associated with an increase in
mechanistic target of rapamycin complex (mTORC) 1 activity in adipose tissue. We
investigated herein the effects of pharmacological mTORC1 inhibition in the development of
adipose tissue inflammation induced by high-fat diet (HFD) feeding, as well as in the
polarization, metabolism and function of bone marrow-derived macrophages (BMDM). For
this, C57BL/6J mice fed with a standard chow diet or a HFD (60% of calories from fat) and …
mechanistic target of rapamycin complex (mTORC) 1 activity in adipose tissue. We
investigated herein the effects of pharmacological mTORC1 inhibition in the development of
adipose tissue inflammation induced by high-fat diet (HFD) feeding, as well as in the
polarization, metabolism and function of bone marrow-derived macrophages (BMDM). For
this, C57BL/6J mice fed with a standard chow diet or a HFD (60% of calories from fat) and …