[HTML][HTML] Everolimus, an mTORC1/2 inhibitor, in ART-suppressed individuals who received solid organ transplantation: A prospective study
Pharmacologic inhibition of the mammalian target of rapamycin (mTOR) in the setting of
renal transplantation has previously been associated with lower human immunodeficiency
virus 1 (HIV-1) DNA burden, and in vitro studies suggest that mTOR inhibition may lead to
HIV transcriptional silencing. Because prospective clinical trials are lacking, we conducted
an open-label, single-arm study to determine the impact of the broad mTOR inhibitor,
everolimus, on residual HIV burden, transcriptional gene expression profiles, and immune …
renal transplantation has previously been associated with lower human immunodeficiency
virus 1 (HIV-1) DNA burden, and in vitro studies suggest that mTOR inhibition may lead to
HIV transcriptional silencing. Because prospective clinical trials are lacking, we conducted
an open-label, single-arm study to determine the impact of the broad mTOR inhibitor,
everolimus, on residual HIV burden, transcriptional gene expression profiles, and immune …