[HTML][HTML] An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia
SM Dillon, EJ Lee, CV Kotter, GL Austin, Z Dong… - Mucosal …, 2014 - Elsevier
Abstract Human immunodeficiency virus-1 (HIV-1) infection disrupts the intestinal immune
system, leading to microbial translocation and systemic immune activation. We investigated
the impact of HIV-1 infection on the intestinal microbiome and its association with mucosal T-
cell and dendritic cell (DC) frequency and activation, as well as with levels of systemic T-cell
activation, inflammation, and microbial translocation. Bacterial 16S ribosomal DNA
sequencing was performed on colon biopsies and fecal samples from subjects with chronic …
system, leading to microbial translocation and systemic immune activation. We investigated
the impact of HIV-1 infection on the intestinal microbiome and its association with mucosal T-
cell and dendritic cell (DC) frequency and activation, as well as with levels of systemic T-cell
activation, inflammation, and microbial translocation. Bacterial 16S ribosomal DNA
sequencing was performed on colon biopsies and fecal samples from subjects with chronic …