[HTML][HTML] Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS
AM Mueller, BH Yoon, SA Sadiq - Journal of Biological Chemistry, 2014 - ASBMB
Hyaluronan (HA) may have proinflammatory roles in the context of CNS autoimmunity. It
accumulates in demyelinated multiple sclerosis (MS) lesions, promotes antigen
presentation, and enhances T-cell activation and proliferation. HA facilitates lymphocyte
binding to vessels and CNS infiltration at the CNS vascular endothelium. Furthermore, HA
signals through Toll-like receptors 2 and 4 to stimulate inflammatory gene expression. We
assessed the role of HA in experimental autoimmune encephalomyelitis (EAE), an animal …
accumulates in demyelinated multiple sclerosis (MS) lesions, promotes antigen
presentation, and enhances T-cell activation and proliferation. HA facilitates lymphocyte
binding to vessels and CNS infiltration at the CNS vascular endothelium. Furthermore, HA
signals through Toll-like receptors 2 and 4 to stimulate inflammatory gene expression. We
assessed the role of HA in experimental autoimmune encephalomyelitis (EAE), an animal …