[HTML][HTML] 4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition
4-Methylumbelliferone (4-MU) inhibits hyaluronan (HA) synthesis and is an approved drug
used for managing biliary spasm. However, rapid and efficient glucuronidation is thought to
limit its utility for systemically inhibiting HA synthesis. In particular, 4-MU in mice has a short
half-life, causing most of the drug to be present as the metabolite 4-methylumbelliferyl
glucuronide (4-MUG), which makes it remarkable that 4-MU is effective at all. We report here
that 4-MUG contributes to HA synthesis inhibition. We observed that oral administration of 4 …
used for managing biliary spasm. However, rapid and efficient glucuronidation is thought to
limit its utility for systemically inhibiting HA synthesis. In particular, 4-MU in mice has a short
half-life, causing most of the drug to be present as the metabolite 4-methylumbelliferyl
glucuronide (4-MUG), which makes it remarkable that 4-MU is effective at all. We report here
that 4-MUG contributes to HA synthesis inhibition. We observed that oral administration of 4 …