[HTML][HTML] Inactivation of UCP1 and the glycerol phosphate cycle synergistically increases energy expenditure to resist diet-induced obesity
R Anunciado-Koza, J Ukropec, RA Koza… - Journal of biological …, 2008 - ASBMB
Our current paradigm for obesity assumes that reduced thermogenic capacity increases
susceptibility to obesity, whereas enhanced thermogenic capacity protects against obesity.
Here we report that elimination of two major thermogenic pathways encoded by the
mitochondrial uncoupling protein (Ucp1) and mitochondrial glycerol-3-phosphate
dehydrogenase (Gdm) result in mice with increased resistance to diet-induced obesity when
housed at 28° C, provided prior adaptation occurred at 20° C. Obesity resistant Gdm-/-· Ucp1 …
susceptibility to obesity, whereas enhanced thermogenic capacity protects against obesity.
Here we report that elimination of two major thermogenic pathways encoded by the
mitochondrial uncoupling protein (Ucp1) and mitochondrial glycerol-3-phosphate
dehydrogenase (Gdm) result in mice with increased resistance to diet-induced obesity when
housed at 28° C, provided prior adaptation occurred at 20° C. Obesity resistant Gdm-/-· Ucp1 …