The possibility that brown adipose tissue thermogenesis can be recruited in order to combat
the development of obesity has led to a high interest in the identification of “browning
agents”, ie agents that increase the amount and activity of UCP1 in brown and brite/beige
adipose tissues. However, functional analysis of the browning process yields confusingly
different results when the analysis is performed in one of two alternative steps. Thus, in one
of the steps, using cold acclimation as a potent model browning agent, we find that if the …