Obesity induces accumulation of adipose tissue macrophages (ATMs), which contribute to
both local and systemic inflammation and modulate insulin sensitivity. Adipocyte lipolysis
during fasting and weight loss also leads to ATM accumulation, but without proinflammatory
activation suggesting distinct mechanisms of ATM recruitment. We examined the possibility
that specific lipid mediators with anti-inflammatory properties are released from adipocytes
undergoing lipolysis to induce macrophage migration. In the present study, we showed that …