[HTML][HTML] Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation [S]

AS Haka, VC Barbosa-Lorenzi, HJ Lee… - Journal of lipid …, 2016 - ASBMB
Many types of apoptotic cells are phagocytosed and digested by macrophages. Adipocytes
can be hundreds of times larger than macrophages, so they are too large to be digested by
conventional phagocytic processes. The nature of the interaction between macrophages
and apoptotic adipocytes has not been studied in detail. We describe a cellular process,
termed exophagy, that is important for macrophage clearance of dead adipocytes and
adipose tissue homeostasis. Using mouse models of obesity, human tissue, and a cell …