The extracellular matrix (ECM) is an essential component of the human body that is
responsible for the proper function of various organs. Changes in the ECM have been
implicated in the pathogenesis of several cardiovascular conditions including
atherosclerosis, restenosis, and heart failure. Matrix components, such as collagens and
noncollagenous proteins, influence the function and activity of vascular cells, particularly
vascular smooth muscle cells and macrophages. Matrix proteins have been shown to be …