Billions of cells undergo apoptosis daily and are swiftly removed by macrophages through
an evolutionarily conserved program termed" efferocytosis". Consequently, macromolecules
within an apoptotic cell significantly burden a phagocyte with nutrients, such as lipids,
oligonucleotides, and amino acids. In response to this nutrient overload, metabolic
reprogramming must occur for the process of efferocytosis to remain non-phlogistic and to
execute successive rounds of efferocytosis. The inability to undergo metabolic …