Emigration of monocyte-derived cells to lymph nodes during resolution of inflammation and its failure in atherosclerosis
GJ Randolph - Current opinion in lipidology, 2008 - journals.lww.com
Current opinion in lipidology, 2008•journals.lww.com
Impaired egress would be expected to compound macrophage accumulation within
plaques, contribute to build-up of necrotic pools, and explain in part the reticence of many
plaques to regress, or resolve. Restoration of the capacity of monocyte-derived cells to leave
plaques would, by contrast, be expected to facilitate regression, but it remains to be
determined whether restoring egress may sometimes provoke unwanted outcomes as well.
plaques, contribute to build-up of necrotic pools, and explain in part the reticence of many
plaques to regress, or resolve. Restoration of the capacity of monocyte-derived cells to leave
plaques would, by contrast, be expected to facilitate regression, but it remains to be
determined whether restoring egress may sometimes provoke unwanted outcomes as well.
Summary
Impaired egress would be expected to compound macrophage accumulation within plaques, contribute to build-up of necrotic pools, and explain in part the reticence of many plaques to regress, or resolve. Restoration of the capacity of monocyte-derived cells to leave plaques would, by contrast, be expected to facilitate regression, but it remains to be determined whether restoring egress may sometimes provoke unwanted outcomes as well.
Lippincott Williams & Wilkins