Mitochondrial dysfunction is associated with a large number of human diseases, including
neurological and muscular degeneration, cardiovascular disorders, obesity, diabetes, aging
and rare mitochondrial diseases. Replacement of dysfunctional mitochondria with functional
exogenous mitochondria is proposed as a general principle to treat these diseases. Here we
found that mitochondria isolated from human hepatoma cell could naturally enter human
neuroblastoma SH-SY5Y cell line, and when the mitochondria were intravenously injected …