E-selectin plays a role in the binding and extravasation of leukocytes from the bloodstream.
The E-selectin gene is rapidly and transiently expressed by endothelial cells activated by
inflammatory stimuli. Despite the identification of factors critical for cytokine-induced
activation of the E-selectin promoter, little is known about the mechanisms that restrict the
gene expression to endothelial cells. We used in vivo approaches to characterize the E-
selectin promoter in primary cultures of human umbilical vein endothelial cells and umbilical …