[HTML][HTML] Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein
M Iizuka, B Stillman - Journal of Biological Chemistry, 1999 - ASBMB
The origin recognition complex (ORC) is an initiator protein for DNA replication, but also
effects transcriptional silencing in Saccharomyces cerevisiae and heterochromatin function
in Drosophila. It is not known, however, whether any of these functions of ORC is conserved
in mammals. We report the identification of a novel protein, HBO1 (histone acetyltransferase
binding to ORC), that interacts with human ORC1 protein, the largest subunit of ORC. HBO1
exists as part of a multisubunit complex that possesses histone H3 and H4 acetyltransferase …
effects transcriptional silencing in Saccharomyces cerevisiae and heterochromatin function
in Drosophila. It is not known, however, whether any of these functions of ORC is conserved
in mammals. We report the identification of a novel protein, HBO1 (histone acetyltransferase
binding to ORC), that interacts with human ORC1 protein, the largest subunit of ORC. HBO1
exists as part of a multisubunit complex that possesses histone H3 and H4 acetyltransferase …