[HTML][HTML] Senescence in tissue samples of humans with age-related diseases: A systematic review
CSL Tuttle, SWM Luesken, MEC Waaijer… - Ageing Research …, 2021 - Elsevier
CSL Tuttle, SWM Luesken, MEC Waaijer, AB Maier
Ageing Research Reviews, 2021•ElsevierBackground Higher numbers of senescent cells have been implicated in age-related
disease pathologies. However, whether different diseases have different senescent
phenotypes is unknown. Here we provide a systematic overview of the current available
evidence of senescent cells in age-related diseases pathologies in humans and the markers
currently used to detect senescence levels in humans. Methods PubMed, Web of Science
and EMBASE were systematically searched from inception to the 29 th of September 2019 …
disease pathologies. However, whether different diseases have different senescent
phenotypes is unknown. Here we provide a systematic overview of the current available
evidence of senescent cells in age-related diseases pathologies in humans and the markers
currently used to detect senescence levels in humans. Methods PubMed, Web of Science
and EMBASE were systematically searched from inception to the 29 th of September 2019 …
Background
Higher numbers of senescent cells have been implicated in age-related disease pathologies. However, whether different diseases have different senescent phenotypes is unknown. Here we provide a systematic overview of the current available evidence of senescent cells in age-related diseases pathologies in humans and the markers currently used to detect senescence levels in humans.
Methods
PubMed, Web of Science and EMBASE were systematically searched from inception to the 29th of September 2019, using keywords related to ‘senescence’, ‘age-related diseases’ and ‘biopsies’.
Results
In total 12,590 articles were retrieved of which 103 articles were included in this review. The role of senescence in age-related disease has been assessed in 9 different human organ system and 27 different age-related diseases of which heart (27/103) and the respiratory systems (18/103) are the most investigated. Overall, 27 different markers of senescence have been used to determine cellular senescence and the cell cycle regulator p16ink4a is most often used (23/27 age-related pathologies).
Conclusion
This review demonstrates that a higher expression of senescence markers are observed within disease pathologies. However, not all markers to detect senescence have been assessed in all tissue types.
Elsevier
