The Son of sevenless Gene Product: a Putative Activator of Ras
L Bonfini, CA Karlovich, C Dasgupta, U Banerjee - Science, 1992 - science.org
L Bonfini, CA Karlovich, C Dasgupta, U Banerjee
Science, 1992•science.orgThe Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless
and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated
and sequenced. Its product is a 1595-amino acid protein similar to the CDC25 protein in
Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These
results imply a role for the ras pathway in Drosophila neuronal development.
and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated
and sequenced. Its product is a 1595-amino acid protein similar to the CDC25 protein in
Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These
results imply a role for the ras pathway in Drosophila neuronal development.
The Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated and sequenced. Its product is a 1595-amino acid protein similar to the CDC25 protein in Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These results imply a role for the ras pathway in Drosophila neuronal development.
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