[HTML][HTML] Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction

Y Ikeda, K Sato, DR Pimentel, F Sam, RJ Shaw… - Journal of Biological …, 2009 - ASBMB
LKB1 encodes a serine/threonine kinase, which functions upstream of the AMP-activated
protein kinase (AMPK) superfamily. To clarify the role of LKB1 in heart, we generated and
characterized cardiac myocyte-specific LKB1 knock-out (KO) mice using α-myosin heavy
chain-Cre deletor strain. LKB1-KO mice displayed biatrial enlargement with atrial fibrillation
and cardiac dysfunction at 4 weeks of age. Left ventricular hypertrophy was observed in
LKB1-KO mice at 12 weeks but not 4 weeks of age. Collagen I and III mRNA expression was …