Convection-enhanced delivery of therapeutic agents into the brain
MA Vogelbaum, CA Iannotti - Handbook of Clinical Neurology, 2012 - Elsevier
Treatment of malignant gliomas represents one of the most formidable challenges in
oncology. The incidence of primary brain tumors is increasing and more than 17 000 cases
are diagnosed annually in the USA. Malignant gliomas, including glioblastoma multiforme
(GBM) and anaplastic astrocytoma (AA) are the most common histological types, and the
invasiveness of these tumors eliminates the possibility of complete surgical resection. The
combination of surgery, radiation, and chemotherapy yields median survivals of less than 1 …
oncology. The incidence of primary brain tumors is increasing and more than 17 000 cases
are diagnosed annually in the USA. Malignant gliomas, including glioblastoma multiforme
(GBM) and anaplastic astrocytoma (AA) are the most common histological types, and the
invasiveness of these tumors eliminates the possibility of complete surgical resection. The
combination of surgery, radiation, and chemotherapy yields median survivals of less than 1 …