CCL3 and CCL4 actively recruit CD8+ T cells

K Honey - Nature Reviews Immunology, 2006 - nature.com
K Honey
Nature Reviews Immunology, 2006nature.com
It is clear that antigen-presenting cells, such as dendritic cells (DCs), are necessary
mediators of the help provided by CD4+ T cells to CD8+ T cells. However, many questions
remain regarding how these three cell types interact and whether such interactions are
regulated or occur randomly. Answers to some of these questions have now been provided
by a study published in Nature showing that naive CD8+ T cells are actively recruited to sites
of antigen-specific interactions between CD4+ T cells and DCs. In this study, Castellino et al …
It is clear that antigen-presenting cells, such as dendritic cells (DCs), are necessary mediators of the help provided by CD4+ T cells to CD8+ T cells. However, many questions remain regarding how these three cell types interact and whether such interactions are regulated or occur randomly. Answers to some of these questions have now been provided by a study published in Nature showing that naive CD8+ T cells are actively recruited to sites of antigen-specific interactions between CD4+ T cells and DCs. In this study, Castellino et al. set out to test the hypothesis that CD8+ T cells are actively recruited to DCs that are activated by CD4+ T cells. When immunocompetent mouse recipients of OT-I T cells and OT-II T cells (CD8+ and CD4+ T cells that express a T-cell receptor specific for a peptide consisting of amino-acid residues 257–264 and 323–339 of ovalbumin (OVA), respectively) were immunized with OVA257–264 in adjuvant on both flanks, equal numbers of OT-I T cells were detected in both draining lymph nodes. However, if OVA323–339 was administered to one flank (with either OVA257–264 and adjuvant, or adjuvant alone being concomitantly administered to both flanks), the accumulation of OT-I T cells was greater in that draining lymph node than in the contralateral lymph node. Furthermore, intravital two-photon microscopy showed that, in the presence of OT-II T cells, OT-I T cells came into contact with DCs pulsed with OVA323–339 more often than with unpulsed control DCs.
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