Synaptic disturbances may play a key role in the pathophysiology of Alzheimer's disease. To
characterize differential synaptic alterations in the brains of Alzheimer patients,
chromogranin A, chromogranin B and secretoneurin were applied as soluble constituents for
large dense core vesicles, synaptophysin as a vesicle membrane marker and calbindin as a
cytosolic protein. In controls, chromogranin B and secretogranin are largely co-contained in
interneurons, whereas chromogranin A is mostly found in pyramidal neurons. In Alzheimer's …