[HTML][HTML] Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner
Amino acids exert modulatory effects on proteins involved in control of mRNA translation in
animal cells through the target of rapamycin (TOR) signaling pathway. Here we use oocytes
ofXenopus laevis to investigate mechanisms by which amino acids are" sensed" in animal
cells. Small (∼ 48%) but physiologically relevant increases in intracellular but not
extracellular total amino acid concentration (or Leu or Trp but not Ala, Glu, or Gln alone)
resulted in increased phosphorylation of p70 S6K and its substrate ribosomal protein S6 …
animal cells through the target of rapamycin (TOR) signaling pathway. Here we use oocytes
ofXenopus laevis to investigate mechanisms by which amino acids are" sensed" in animal
cells. Small (∼ 48%) but physiologically relevant increases in intracellular but not
extracellular total amino acid concentration (or Leu or Trp but not Ala, Glu, or Gln alone)
resulted in increased phosphorylation of p70 S6K and its substrate ribosomal protein S6 …