Challenges in circulating tumour cell research
C Alix-Panabières, K Pantel - Nature Reviews Cancer, 2014 - nature.com
Nature Reviews Cancer, 2014•nature.com
During the past ten years, circulating tumour cells (CTCs) have received enormous attention
as new biomarkers and the subject of basic research. Although CTCs are already used in
numerous clinical trials, their clinical utility is still under investigation. Many issues regarding
the detection and characterization of CTCs remain unknown. In this Opinion article, we
propose a conceptual framework of CTC assays and point out current challenges of CTC
research, which might structure this dynamic field of translational cancer research.
as new biomarkers and the subject of basic research. Although CTCs are already used in
numerous clinical trials, their clinical utility is still under investigation. Many issues regarding
the detection and characterization of CTCs remain unknown. In this Opinion article, we
propose a conceptual framework of CTC assays and point out current challenges of CTC
research, which might structure this dynamic field of translational cancer research.
Abstract
During the past ten years, circulating tumour cells (CTCs) have received enormous attention as new biomarkers and the subject of basic research. Although CTCs are already used in numerous clinical trials, their clinical utility is still under investigation. Many issues regarding the detection and characterization of CTCs remain unknown. In this Opinion article, we propose a conceptual framework of CTC assays and point out current challenges of CTC research, which might structure this dynamic field of translational cancer research.
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