[HTML][HTML] Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice
ME Coleman, F DeMayo, KC Yin, HM Lee… - Journal of Biological …, 1995 - ASBMB
The avian skeletal α-actin gene was used as a template for construction of a myogenic
expression vector that was utilized to direct expression of a human IGF-I cDNA in cultured
muscle cells and in striated muscle of transgenic mice. The proximal promoter region,
together with the first intron and 1.8 kilobases of 3'-noncoding flanking sequence of the
avian skeletal α-actin gene directed high level expression of human insulin-like growth
factor I (IGF-I) in stably transfected C 2 C 12 myoblasts and transgenic mice. Expression of …
expression vector that was utilized to direct expression of a human IGF-I cDNA in cultured
muscle cells and in striated muscle of transgenic mice. The proximal promoter region,
together with the first intron and 1.8 kilobases of 3'-noncoding flanking sequence of the
avian skeletal α-actin gene directed high level expression of human insulin-like growth
factor I (IGF-I) in stably transfected C 2 C 12 myoblasts and transgenic mice. Expression of …