Triggering the interferon antiviral response through an IKK-related pathway
Science, 2003•science.org
Rapid induction of type I interferon expression, a central event in establishing the innate
antiviral response, requires cooperative activation of numerous transcription factors.
Although signaling pathways that activate the transcription factors nuclear factor κB and ATF-
2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3
and IRF-7 has remained a critical missing link in understanding interferon signaling. We
report here that the IκB kinase (IKK)–related kinases IKKϵ and TANK-binding kinase 1 are …
antiviral response, requires cooperative activation of numerous transcription factors.
Although signaling pathways that activate the transcription factors nuclear factor κB and ATF-
2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3
and IRF-7 has remained a critical missing link in understanding interferon signaling. We
report here that the IκB kinase (IKK)–related kinases IKKϵ and TANK-binding kinase 1 are …
Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor κB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IκB kinase (IKK)–related kinases IKKϵ and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.
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