Intrauterine administration of endotoxin leads to motor deficits in a rabbit model: a link between prenatal infection and cerebral palsy
F Saadani-Makki, S Kannan, X Lu, J Janisse… - American journal of …, 2008 - Elsevier
OBJECTIVE: This study was undertaken to determine whether maternal intrauterine
endotoxin administration leads to neurobehavioral deficits in newborn rabbits. STUDY
DESIGN: Pregnant New Zealand white rabbits were injected with 1 mL saline solution (n= 8)
or 20 μg/kg of lipopolysaccharide in saline solution (n= 8) into the uterine wall on day 28/31
of gestation. On postnatal day 1, kits (saline solution [n= 30] and lipolysaccharide in saline
solution [n= 18] from 4 consecutive litters) underwent neurobehavioral testing. Neonatal …
endotoxin administration leads to neurobehavioral deficits in newborn rabbits. STUDY
DESIGN: Pregnant New Zealand white rabbits were injected with 1 mL saline solution (n= 8)
or 20 μg/kg of lipopolysaccharide in saline solution (n= 8) into the uterine wall on day 28/31
of gestation. On postnatal day 1, kits (saline solution [n= 30] and lipolysaccharide in saline
solution [n= 18] from 4 consecutive litters) underwent neurobehavioral testing. Neonatal …