Strong IgG antibody responses to Borrelia burgdorferi glycolipids in patients with Lyme arthritis, a late manifestation of the infection
KL Jones, RJ Seward, G Ben-Menachem… - Clinical …, 2009 - Elsevier
In this study, the membrane lipids of B. burgdorferi were separated into 16 fractions; the
components in each fraction were identified, and the immunogenicity of each fraction was
determined by ELISA using sera from Lyme disease patients. Only the 2 glycolipids,
acylated cholesteryl galactoside (ACG, BbGL-I) and monogalactosyl diacylglycerol (MgalD,
BbGL-II), were immunogenic. Early in the infection, 24 of 84 patients (29%) who were
convalescent from erythema migrans and 19 of the 35 patients (54%) with neuroborreliosis …
components in each fraction were identified, and the immunogenicity of each fraction was
determined by ELISA using sera from Lyme disease patients. Only the 2 glycolipids,
acylated cholesteryl galactoside (ACG, BbGL-I) and monogalactosyl diacylglycerol (MgalD,
BbGL-II), were immunogenic. Early in the infection, 24 of 84 patients (29%) who were
convalescent from erythema migrans and 19 of the 35 patients (54%) with neuroborreliosis …