[HTML][HTML] FGF21 mediates the lipid metabolism response to amino acid starvation

AL De Sousa-Coelho, J Relat, E Hondares… - Journal of lipid …, 2013 - ASBMB
Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The
hormone fibroblast growth factor 21 (FGF21), which is critical to the adaptive metabolic
response to starvation, is also induced under amino acid deprivation. Upon leucine
deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver
and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in
white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under …