[HTML][HTML] BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells
Bone morphogenetic protein-9 (BMP-9) is a circulating cytokine that is known to play an
essential role in the endothelial homeostasis and the binding of BMP-9 to the receptor
activin-like kinase 1 (ALK-1) promotes endothelial cell quiescence. Previously, using an
unbiased screen, we identified ALK-1 as a high-capacity receptor for low-density lipoprotein
(LDL) in endothelial cells that mediates its transcytosis in a nondegradative manner. Here
we examine the crosstalk between BMP-9 and LDL and how it influences their interactions …
essential role in the endothelial homeostasis and the binding of BMP-9 to the receptor
activin-like kinase 1 (ALK-1) promotes endothelial cell quiescence. Previously, using an
unbiased screen, we identified ALK-1 as a high-capacity receptor for low-density lipoprotein
(LDL) in endothelial cells that mediates its transcytosis in a nondegradative manner. Here
we examine the crosstalk between BMP-9 and LDL and how it influences their interactions …