Proteins secreted from adipose tissue are increasingly recognized to play an important role
in the regulation of glucose metabolism. However, much less is known about their effect on
lipid metabolism. The fasting-induced adipose factor (FIAF/angiopoietin-like protein
4/peroxisome proliferator-activated receptor γ angiopoietin-related protein) was previously
identified as a target of hypolipidemic fibrate drugs and insulin-sensitizing
thiazolidinediones. Using transgenic mice that mildly overexpress FIAF in peripheral tissues …