Effect of inorganic nitrite vs placebo on exercise capacity among patients with heart failure with preserved ejection fraction: the INDIE-HFpEF randomized clinical trial
Importance There are few effective treatments for heart failure with preserved ejection
fraction (HFpEF). Short-term administration of inorganic nitrite or nitrate preparations has
been shown to enhance nitric oxide signaling, which may improve aerobic capacity in
HFpEF. Objective To determine the effect of 4 weeks' administration of inhaled, nebulized
inorganic nitrite on exercise capacity in HFpEF. Design, Setting, and Participants
Multicenter, double-blind, placebo-controlled, 2-treatment, crossover trial of 105 patients …
fraction (HFpEF). Short-term administration of inorganic nitrite or nitrate preparations has
been shown to enhance nitric oxide signaling, which may improve aerobic capacity in
HFpEF. Objective To determine the effect of 4 weeks' administration of inhaled, nebulized
inorganic nitrite on exercise capacity in HFpEF. Design, Setting, and Participants
Multicenter, double-blind, placebo-controlled, 2-treatment, crossover trial of 105 patients …