[HTML][HTML] Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin–stimulated, cAMP-mediated lipolysis
Lipid droplets (LD) are dynamic organelles involved in intracellular lipid metabolism in
almost all eukaryotic cells, and LD-associated proteins tightly regulate their dynamics. One
LD coat protein is caveolin-1 (Cav-1), an essential component for caveola assembly in
highly differentiated cells, including adipocytes, smooth muscle cells, and endothelial cells
(EC). However, the role of Cav-1 in LD dynamics is unclear. Here we report that EC lacking
Cav-1 exhibit impaired LD formation. The decreased LD formation is due to enhanced …
almost all eukaryotic cells, and LD-associated proteins tightly regulate their dynamics. One
LD coat protein is caveolin-1 (Cav-1), an essential component for caveola assembly in
highly differentiated cells, including adipocytes, smooth muscle cells, and endothelial cells
(EC). However, the role of Cav-1 in LD dynamics is unclear. Here we report that EC lacking
Cav-1 exhibit impaired LD formation. The decreased LD formation is due to enhanced …