New insights into the formation and resolution of ultra-fine anaphase bridges

KL Chan, ID Hickson - Seminars in cell & developmental biology, 2011 - Elsevier
KL Chan, ID Hickson
Seminars in cell & developmental biology, 2011Elsevier
Recent data indicate an unexpected requirement for proteins that were hitherto considered
to be dedicated to DNA repair to facilitate the faithful disjunction of sister chromatids in
anaphase. These include the Bloom's syndrome gene product, BLM and its partners, as well
as a number of proteins that are important for preventing Fanconi anemia (FA) in man. As
part of an analysis of the roles of these proteins in mitosis, we identified a novel class of
anaphase bridge structure, called an ultra-fine anaphase bridge (UFB). These UFBs are …
Recent data indicate an unexpected requirement for proteins that were hitherto considered to be dedicated to DNA repair to facilitate the faithful disjunction of sister chromatids in anaphase. These include the Bloom's syndrome gene product, BLM and its partners, as well as a number of proteins that are important for preventing Fanconi anemia (FA) in man. As part of an analysis of the roles of these proteins in mitosis, we identified a novel class of anaphase bridge structure, called an ultra-fine anaphase bridge (UFB). These UFBs are also defined by the presence of a SNF2 family protein called PICH. In this review, we will discuss the possible sources of UFBs, and how the BLM, PICH and FA proteins might serve to process these structures in order to maintain genome stability.
Elsevier