Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that are regulated by
inflammatory signals to mediate changes in extracellular matrix. Members of the MMP family
share sequence homology, act on interstitial protein substrates, acutely participate in
inflammatory processes and chronically mediate tissue remodelling. MMPs are important in
vascular remodelling, not only in the overall vasculature architecture but also, more
importantly, in the advancing atherosclerotic plaque. MMP activation modifies the …