Mitochondrial dependency in progression of acute myeloid leukemia

NP Basak, S Banerjee - Mitochondrion, 2015 - Elsevier
Acute myeloid leukemia (AML) is a clonal hematopoietic malignant disorder which arises
due to dysregulated differentiation, uncontrolled growth and inhibition of apoptosis leading
to the accumulation of immature myeloid progenitor in the bone marrow. The heterogeneity
of the disease at the molecular and cytogenetic level has led to the identification of several
alteration of biological and clinical significance. One of the alterations which have gained
attention in recent times is the altered energy and metabolic dependency of cancer originally …