Supraglottic laryngeal tumor microenvironmental factors facilitate STAT3 dependent pro-tumorigenic switch in tumor associated macrophages to render utmost …
KK Goswami, S Barik, S Banerjee, AK Bhowmick… - Immunology …, 2013 - Elsevier
Content of tumor microenvironment (TME) is varied greatly among different types of
laryngeal tumors, namely, supraglottic, glottic and subglottic tumors. These three different
TMEs shape infiltrating monocytes/macrophages toward M2 genotypes in variable degrees.
Results obtained from in vitro studies demonstrated extent of expression of M2 phenotypic
features on macrophages was maximum after their exposure to supraglottic laryngeal tumor
cell lysates (SLTCL) than glottic or subglottic lysates. Moreover, M2 macrophages generated …
laryngeal tumors, namely, supraglottic, glottic and subglottic tumors. These three different
TMEs shape infiltrating monocytes/macrophages toward M2 genotypes in variable degrees.
Results obtained from in vitro studies demonstrated extent of expression of M2 phenotypic
features on macrophages was maximum after their exposure to supraglottic laryngeal tumor
cell lysates (SLTCL) than glottic or subglottic lysates. Moreover, M2 macrophages generated …