Deregulation of the HOXA9/MEIS1 axis in acute leukemia
CT Collins, JL Hess - Current opinion in hematology, 2016 - journals.lww.com
CT Collins, JL Hess
Current opinion in hematology, 2016•journals.lww.comHOXA9 deregulation underlies a large subset of aggressive acute leukemias.
Understanding the mechanisms regulating the expression and activity of HOXA9, along with
its critical downstream targets, shows promise for the development of more selective and
effective leukemia therapies.
Understanding the mechanisms regulating the expression and activity of HOXA9, along with
its critical downstream targets, shows promise for the development of more selective and
effective leukemia therapies.
Summary
HOXA9 deregulation underlies a large subset of aggressive acute leukemias. Understanding the mechanisms regulating the expression and activity of HOXA9, along with its critical downstream targets, shows promise for the development of more selective and effective leukemia therapies.
Lippincott Williams & Wilkins