The chromosome 21 transcription factor ETS2 transactivates the β-APP promoter: implications for Down syndrome
EW Wolvetang, OM Bradfield, M Tymms… - … et Biophysica Acta (BBA …, 2003 - Elsevier
The gene that codes for β-amyloid precursor protein (β-APP), a protein centrally involved in
senile plaque formation in Down syndrome (DS) and Alzheimer's disease (AD), is located on
chromosome 21. In DS β-APP expression is three-to fourfold higher than what is expected
from the 1.5-fold increased gene load, suggesting that other genes on chromosome 21
directly or indirectly can further up-regulate β-APP. Here we show that the chromosome 21
transcription factor ETS2 transactivates the β-APP gene via specific Ets binding sites in the β …
senile plaque formation in Down syndrome (DS) and Alzheimer's disease (AD), is located on
chromosome 21. In DS β-APP expression is three-to fourfold higher than what is expected
from the 1.5-fold increased gene load, suggesting that other genes on chromosome 21
directly or indirectly can further up-regulate β-APP. Here we show that the chromosome 21
transcription factor ETS2 transactivates the β-APP gene via specific Ets binding sites in the β …