Fecal Microbiota Transplant for Refractory Clostridium difficile Infection Interrupts 25-Year History of Recurrent Urinary Tract Infections
Open forum infectious diseases, 2018•academic.oup.com
DISCUSSION FMT is safe and effective for recurrent CDI [1]. It has also emerged as potential
therapy for decolonization of MDR organisms (MDROs), offering a safe and possibly cost-
effective strategy for tackling antibiotic resistance beyond current efforts to improve antibiotic
stewardship and prevent infection [2]. Intestinal MDRO decolonization after FMT has been
described in case reports, retrospective studies, and a prospective single-center study [3–5].
However, MDRO eradication from nongastrointestinal body sites is not as well described [6] …
therapy for decolonization of MDR organisms (MDROs), offering a safe and possibly cost-
effective strategy for tackling antibiotic resistance beyond current efforts to improve antibiotic
stewardship and prevent infection [2]. Intestinal MDRO decolonization after FMT has been
described in case reports, retrospective studies, and a prospective single-center study [3–5].
However, MDRO eradication from nongastrointestinal body sites is not as well described [6] …
DISCUSSION
FMT is safe and effective for recurrent CDI [1]. It has also emerged as potential therapy for decolonization of MDR organisms (MDROs), offering a safe and possibly cost-effective strategy for tackling antibiotic resistance beyond current efforts to improve antibiotic stewardship and prevent infection [2].
Intestinal MDRO decolonization after FMT has been described in case reports, retrospective studies, and a prospective single-center study [3–5]. However, MDRO eradication from nongastrointestinal body sites is not as well described [6]. A recent review found that FMT for recurrent Clostridium difficile infection (RCDI) was associated with decreased UTI frequency and improved antibiotic susceptibility profiles [7]. Case reports have also described interruption of recurrent UTIs with a Verona integron-encoded metallo-β-lactamase-positive
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