Autophagy-dependent viral recognition by plasmacytoid dendritic cells
Science, 2007•science.org
Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of
Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA)
viruses occur only after live viral infection. We present evidence here that the recognition of
such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the
lysosome by the process of autophagy. In addition, autophagy was found to be required for
the production of interferon-α by pDCs. These results support a key role for autophagy in …
Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA)
viruses occur only after live viral infection. We present evidence here that the recognition of
such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the
lysosome by the process of autophagy. In addition, autophagy was found to be required for
the production of interferon-α by pDCs. These results support a key role for autophagy in …
Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA) viruses occur only after live viral infection. We present evidence here that the recognition of such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy. In addition, autophagy was found to be required for the production of interferon-α by pDCs. These results support a key role for autophagy in mediating ssRNA virus detection and interferon-α secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7.
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