Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial

SP Costello, PA Hughes, O Waters, RV Bryant… - Jama, 2019 - jamanetwork.com
Importance High-intensity, aerobically prepared fecal microbiota transplantation (FMT) has
demonstrated efficacy in treating active ulcerative colitis (UC). FMT protocols involving
anaerobic stool processing methods may enhance microbial viability and allow efficacy with
a lower treatment intensity. Objective To assess the efficacy of a short duration of FMT
therapy to induce remission in UC using anaerobically prepared stool. Design, Setting, and
Participants A total of 73 adults with mild to moderately active UC were enrolled in a …