[HTML][HTML] Cell surface heparan sulfate proteoglycans: selective regulators of ligand-receptor encounters
PW Park, O Reizes, M Bernfield - Journal of Biological Chemistry, 2000 - ASBMB
Cell surface heparan sulfate proteoglycans (HSPGs), 1 substantially more abundant than
most receptors, modulate encounters of extracellular protein ligands with their receptors by
forming HS-protein complexes. Two gene families account for most cell surface HSPGs.
Both consist of discrete core proteins covalently attached to two or three chains of HS, an N-
and O-sulfated linear polysaccharide of repeating disaccharides containing N-
acetylglucosamine (GlcNAc) and uronic acid (glucuronic acid (GlcA) or iduronic acid …
most receptors, modulate encounters of extracellular protein ligands with their receptors by
forming HS-protein complexes. Two gene families account for most cell surface HSPGs.
Both consist of discrete core proteins covalently attached to two or three chains of HS, an N-
and O-sulfated linear polysaccharide of repeating disaccharides containing N-
acetylglucosamine (GlcNAc) and uronic acid (glucuronic acid (GlcA) or iduronic acid …