[HTML][HTML] Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding
CM Allan, CJ Jung, M Larsson, PJ Heizer, Y Tu… - Journal of lipid …, 2017 - ASBMB
Mutation of conserved cysteines in proteins of the Ly6 family cause human disease—
chylomicronemia in the case of glycosylphosphatidylinositol-anchored HDL binding protein
1 (GPIHBP1) and paroxysmal nocturnal hemoglobinuria in the case of CD59. A mutation in a
conserved cysteine in CD59 prevented the protein from reaching the surface of blood cells.
In contrast, mutation of conserved cysteines in human GPIHBP1 had little effect on GPIHBP1
trafficking to the surface of cultured CHO cells. The latter findings were somewhat surprising …
chylomicronemia in the case of glycosylphosphatidylinositol-anchored HDL binding protein
1 (GPIHBP1) and paroxysmal nocturnal hemoglobinuria in the case of CD59. A mutation in a
conserved cysteine in CD59 prevented the protein from reaching the surface of blood cells.
In contrast, mutation of conserved cysteines in human GPIHBP1 had little effect on GPIHBP1
trafficking to the surface of cultured CHO cells. The latter findings were somewhat surprising …