[HTML][HTML] Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding …
AP Beigneux, BSJ Davies, S Tat, J Chen, P Gin… - Journal of Biological …, 2011 - ASBMB
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1)
is an endothelial cell protein that transports lipoprotein lipase (LPL) from the subendothelial
spaces to the capillary lumen. GPIHBP1 contains two main structural motifs, an amino-
terminal acidic domain enriched in aspartates and glutamates and a lymphocyte antigen 6
(Ly6) motif containing 10 cysteines. All of the cysteines in the Ly6 domain are disulfide-
bonded, causing the protein to assume a three-fingered structure. The acidic domain of …
is an endothelial cell protein that transports lipoprotein lipase (LPL) from the subendothelial
spaces to the capillary lumen. GPIHBP1 contains two main structural motifs, an amino-
terminal acidic domain enriched in aspartates and glutamates and a lymphocyte antigen 6
(Ly6) motif containing 10 cysteines. All of the cysteines in the Ly6 domain are disulfide-
bonded, causing the protein to assume a three-fingered structure. The acidic domain of …