Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma
DC Newcomb, JY Cephus, MG Boswell… - Journal of Allergy and …, 2015 - Elsevier
Background Women have an increased prevalence of severe asthma compared with men.
IL-17A is associated with severe asthma and requires IL-23 receptor (IL-23R) signaling,
which is negatively regulated by let-7f microRNA. Objective We sought to Determine the
mechanism by which 17β-estradiol (E2) and progesterone (P4) increase IL-17A production.
Methods IL-17A production was determined by using flow cytometry in TH 17 cells from
women (n= 14) and men (n= 15) with severe asthma. Cytokine levels were measured by …
IL-17A is associated with severe asthma and requires IL-23 receptor (IL-23R) signaling,
which is negatively regulated by let-7f microRNA. Objective We sought to Determine the
mechanism by which 17β-estradiol (E2) and progesterone (P4) increase IL-17A production.
Methods IL-17A production was determined by using flow cytometry in TH 17 cells from
women (n= 14) and men (n= 15) with severe asthma. Cytokine levels were measured by …